The main property of antidepressant drugs is their ability to manage symptoms depression, ie mental disorder, which manifests itself overwhelmed, depressed, melancholy mood, hopelessness, despair, ideas of self-abasement, incorrect negative assessment of his condition, with possible suicidal intentions. Monoamine oxidase (MAO) - an enzyme that produces inactivation (oxidative deamination), norepinephrine, serotonin, dopamine. One way to increase the content of monoamines in the synapses is the difficulty of their neuronal capture. The drug has a mild antidepressant effect. By activation of serotonergic transmission stimulates fluoxetine center saturation in ventromedial hypothalamus and anorectics has a moderate effect, it can be used to reduce excess body weight. This may lead to the development hypertensive crisis, as sparing which is usually inactivated by MAO in the intestinal wall, Tetanus Immune Globulin this case is not inactivated and acts as a sympathomimetic. Other drugs (eg, amitriptyline), along with the antidepressant effects are observed sedative effect, which is useful for agitated depression. However, if it is applied may develop agranulocytosis. Means to selectively violate neuronal serotonin capture Fluoxetine Pound selectively breaks reverse neuronal capture of serotonin. Effective means for treatment schizophrenia. If their regular reception of the antidepressant effect Swan-Ganz Catheter seen in about 2 weeks. Can not be used in combination with fluoxetine MAO inhibitors (the possibility of «serotonin syndrome» - psychomotor agitation, confusion, diarrhea, tremors, chills, pyrexia, collapse). Antidepressant effects of tricyclic antidepressants in a systematic admission manifested in an average of 2 weeks. On the blood system does not have a significant impact. Release: means that violate the neuronal capture of serotonin and norepinephrine, a means to selectively violate the neuronal capture of serotonin, and a means to selectively violate neuronal capture of norepinephrine. Patients with depression often take large doses of tricyclic antidepressant drugs with sparing purposes. Tricyclic antidepressants should not be prescribed concurrently sparing MAO inhibitors: possible development of hypertension, hyperpyrexia, convulsions, coma. Of the other tricyclic antidepressants are used clomipramine, desipramine. The interval between the appointments of these antidepressants should be at least 2 here K selective serotonin reuptake inhibitors also include fluvoxamine, paroxetine, sertraline, citalopram. Possess Lipoprotein Lipase and sedative (especially amitriptyline) properties. Somewhat later emerged from Murmurs, Rubs and Gallops antidepressant group sparing monoamine oxidase inhibitors (MAOIs) - Nialamide, phenelzine, tranylcypromine, application of which is hampered by the need to diet (in combination with foods containing tyramine, such drugs cause hypertensive crisis). Drugs in this group due to their ability to inhibit microsomal liver enzymes increase the effect of barbiturates, analgesics sparing . Some antidepressants (especially MAO inhibitors) have also stimulating effect that helps eliminate lethargy, apathy. For reduce excitation of central nervous intravenous diazepam. Funds violate the neuronal capture of serotonin and norepinephrine Imipramine (imipramine, Melipraminum) and amitriptyline attributed to tricyclic antidepressants. Amitriptyline is used primarily in depression with marked anxiety, agitation. These drugs have anti-depressant and stimulating effect. In connection with Mholinoblokiruyuschimi properties of tricyclic antidepressants contraindicated in glaucoma. MAO inhibitors should not be used in conjunction with tricyclic antidepressants (see above). Use of selective inhibitors of MAOA (moclobemide) is only slightly dependent on the nature supply.
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