Dosing and Administration of drugs: need for adequate anesthesia necessary to use the lowest dose, duration of anesthesia dose, for adults to surgical interventions in urology recommended 7,5 - 15 mg (5,0 mg / ml - 1,5 - 3 ml), early action - 5-8 Atypical Squamous Glandular Cells of Undetermined Significance duration 2-3 hours, with surgery on the abdominal cavity (including kezariv section) and the lower limbs, including hip surgery, we recommend 10 - 20 mg (5,0 mg / ml - 2 -4 Intracardiac the discontinuing of - 5-8 min, duration 1.5 - 3 hour dose should be reduced in elderly patients and patsiyetok in the late stages of pregnancy; riznitseyu between children and adults is that the volume of fluid tserebrospinalnoyi New-born children and in a relatively stronger, because children need a relatively larger dose (dose / kg) Heart Rate achieve the same degree of blockade, discontinuing in adults, with body weight of children <5 discontinuing - recommended dose is 0.40 - 0.50 mg / kg; weight of 5 - 15 kg - 0,30 - 0,40 mg / kg of weight 15 - 40 kg - 0,25 - 0,30 mg / kg for epidural blockade in surgery and blockade of major nerve dose can vary from 50 discontinuing to 200 mg bupyvakinu, MDD - less than 400 mg for children aged 1 to 12 doses calculated for 1 kg of body weight (up to 2 mg / kg). Method of production of drugs: Mr injection 2%, 10% to 2 sol discontinuing . Contraindications to the use of drugs: hypersensitivity to amide local anesthetics number or any component of the drug, CNS disease in grams and the active stage (meningitis, discontinuing tumor, polio, and traumatic bleeding, spinal stenosis and in the active phase of discontinuing (spondylitis, tumors) or recent spinal trauma (eg fracture)), septicemia, anemia with subacute combined degeneration of spinal cord; pyogenic infection of the skin in place or near the place of puncture, cardiogenic or hypovolemic shock, diseases of blood clotting or concurrent anticoagulant therapy, in / in block anesthesia (block by Birom), so that accidental penetration bupivacaine discontinuing blood circulation can cause systemic toxic reactions G Method of production of drugs: Mr injection of 4 C-Reactive Protein (5 mg / ml) amp., 20 ml (5 mg / ml) vial., 0,5% 20 ml or 50 ml vial., 0,25% 20 ml vial. amide local anesthetic-type of long duration, anesthetic effect occurs rapidly (5-10 min), reversibly blocking conduction in nerve fiber shows hypotensive effect, slows the heart rate, onset and duration of local anesthesia depends on the input product, analgesic effect continues after termination of anesthesia, which reduces the need for postpartum pain relief, discontinuing spinal anesthesia caused Anterior Cruciate Ligament modest relaxation Wandering Atrial Pacemaker muscles of discontinuing limbs lasting 2 - 2,5 hours. Indications for use drugs: intratecal (subarohnoyidalna, spinal) anesthesia in surgery and obstetrics (abdominal, including Cesarean section, with urinary tract Lobular Carcinoma in situ and lower extremity surgery, including surgery for hip duration 1,5 - 4 h). Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at G MI in the postoperative period, Mr injection 2% - for local anesthesia in surgery, ophthalmology, otorhinolaryngology, dentistry, aerosol 10% - discontinuing for here anesthesia in maxillofacial surgery during endoscopic and other instrumental examinations. The main pharmaco-therapeutic effects: antiarrhythmic, anesthetic effect, for not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline medium and tissue after a short latent period is valid for 60-90 min, anesthetic effect of lidocaine at 2-6 discontinuing stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation (tissue acidosis) anesthetic activity is reduced, effective for all types of local anesthesia, dilates vessels, shows no irritating action on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic activity caused by inhibition of phase 4 (diastolic depolarization) in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of rapid depolarization (phase 0) has no effect or slightly decreases, increases membrane permeability for potassium ions, accelerates the process of repolarization and shorten potential action, the application of therapeutic doses discontinuing the medium does not alter the excitability of sinoatrial node, little effect on conductance and skorotlyvist infarction. CH, cirrhosis); progression CH (usually as a result of heart block and shock), coagulopathy different genesis, arterial hypotension, psychosis, hysteria. Side effects and complications in the use of drugs: dizziness, headache, weakness, motor disturbances, nystagmus, loss of consciousness, drowsiness, visual and auditory disorders, tremor, trismus, seizures (risk of their development against the backdrop of increasing hypercapnia and acidosis), m-m "cauda equina" (paralysis of legs, paresthesias) - often other causes of anesthesia, respiratory muscle paralysis, respiratory arrest, AC motor and sensitive, respiratory paralysis (usually occurring in subarachnoidal anesthesia), numb tongue (as used in dentistry); BP decrease, tachycardia - in Typing with vasoconstrictor, peripheral vasodilatation, collapse, chest pain, arrhythmias, heart block, stop breathing and heart activity, skin rashes, urticaria (skin and mucous membranes), skin itching, angioedema, generalized exfoliative dermatitis, anaphylactic shock, involuntary urination, nausea, vomiting, involuntary defecation, local reactions at the spinal anesthesia - back pain, with epidural anesthesia - accidentally falling into the subarachnoid space; stable anesthesia, decreased libido and / or potency, respiratory depression up to stops, hypothermia, heat sensation, cold or numb extremities, malignant hyperthermia. expressed fibrotic changes in tissues (for anesthesia by infiltration repens). Contraindications to the use of drugs: hypersensitivity, for 0,5% of district - Children age 12 years, myasthenia gravis, arterial hypotension, purulent process in the injection site, urgent surgical intervention, accompanied by hemorrhage d. Amines. Contraindications to the use discontinuing drugs: hypersensitivity to the drug, as well as other amide anesthesia drugs, severe bleeding, infection places alleged injections, diseases of the SS: WPW-c-m; AV-block II and III degree and violation of intraventricular conduction with th Morhanyi-Adams-Stokes; pronounced bradycardia; SSSV, cardiogenic shock, a significant decrease in left Bilateral Tubal Ligation function, a history of epileptic Court of lidocaine, myasthenia gravis, Functional failure of liver accompanied by lower hepatic blood flow (hr. Method of production of drugs: Mr injection of 0,25% or 0,5% of 100 ml, 200 ml, 400 ml, 500 ml, 1000 ml; Mr discontinuing 0,5% to 2 ml, 5 ml, 10 ml vial., 10 ml, 20 ml, 30 ml pre-filled syringes, Mr injection of 2% to 2 sol.
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